I just went through getting mine on the road for the first time... what engine do you have? Has it been driven a lot or was it sitting for a while?
I'm learning as I go with mine, so maybe some experienced guys can give better advice, but I'd say start with fixing anything that could hurt the engine... find out how if the fuel tank is rusted inside (or just drop a new one in, they're cheap), clean out the fuel lines, and put a new fuel filter in... change the oil and filter... stuff like that.
Then do an engine tune-up - distributor cap and rotor, plugs, wires, coil, air cleaner, all that good stuff, and see how it runs.
Also make sure your brakes are solid before you take it out anywhere.. My first project when I got mine was to replace EVERYTHING just to be sure. New lines, hoses, master cylinder, and rebuilt all the drums. It's easy to do even if you're new to cars, and you can make sure it's safe.
1966 Mustang Convertible. 200 I6 / C4 with large log head, Autolite 2100, COMP Cams 260H, Duraspark II with MSD 6a, and dual exhaust.